2 edition of In vivo properties of Pseudomonas aeruginosa found in the catalog.
In vivo properties of Pseudomonas aeruginosa
Kathryn Helen Ward
by Aston University. Department of Pharmaceutical Sciences in Birmingham
Written in English
Thesis (PhD) - Aston University, 1987.
The in vivo activity of CF against P. aeruginosa was studied in a rabbit pneumonia model. CF was well-tolerated and conferred a survival advantage to . The bacteria Pseudomonas aeruginosa can thrive in environments as different as the moist, warm tissue in our lungs, and the dry, nutrient-deprived .
Chronic Pseudomonas aeruginosa lung infection in cystic fibrosis (CF) patients is caused by biofilm-growing mucoid strains. Biofilms can be prevented by early aggressive antibiotic prophylaxis or therapy, and they can be treated by chronic suppressive therapy. New results from one small trial suggest that addition of oral ciprofloxacin to inhaled tobramycin may reduce lung by: 1 Introduction: Pseudomonas aeruginosa, an opportunist pathogen.- 2 Clinical aspects of mucoid Pseudomonas aeruginosa infections.- 3 The structure and properties of alginate.- 4 Characteristics of mucoid Pseudomonas aeruginosa in vitro and in vivo.- 5 The microcolony mode of growth in vivo - an ecological perspective.- 6 Adherence and the role.
PSEUDOMONAS AERUGINOSA AR-BANK# MIC (µg/ml) RESULTS AND INTERPRETATION DRUG MIC INT DRUG MIC INT Amikacin S Gentamicin 4 S Aztreonam R Imipenem 32 R Cefepime 32 ; R Imipenem+chelators. 2. 16 Ceftazidime The study aimed to discover quorum sensing (QS) inhibitors from marine sponge–derived actinomycetes and analyse its inhibitory activities against QS‐mediated virulence factors in Pseudomonas y‐two actinomycetes isolated from marine invertebrates collected from the western coast of India were screened against the QS indicator strain Chromobacterium violaceum CVCited by:
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The G+C rich Pseudomonas aeruginosa chromosome consists of a conserved core and a variable accessory part. The core genomes of P. aeruginosa strains are largely collinear, exhibit a low rate of sequence polymorphism and contain few loci of high sequence diversity, notably the pyoverdine locus, the flagellar regulon, pilA and the O-antigen biosynthesis locus.
Pseudomonas aeruginosa is a common encapsulated, Gram-negative, rod-shaped bacterium that can cause disease in plants and animals, including humans. A species of considerable medical importance, P.
aeruginosa is a multidrug resistant pathogen recognized for its ubiquity, its intrinsically advanced antibiotic resistance mechanisms, and its association with serious illnesses – hospital Class: Gammaproteobacteria.
Long attributed to the presence of a relatively impermeable outer membrane (OM) that restricts the ready entry of antimicrobials into the cell, the intrinsic multidrug resistance of Pseudomonas aeruginosa results, in fact, from the synergistic activity of the outer membrane barrier and the operation of broadly specific multidrug efflux systems that together limit antimicrobial accumulation in.
The genus Pseudomonas represents a large group of medically and envi ronmentally important bacteria. Interest in these bacteria is reflected in the extensive number of publications devoted to original research, re views, and books on this subject.
In this volume selected areas of Pseu domonas research are presented in depth by persons who have been active in their fields over many years. Chronic Pseudomonas aeruginosa lung infection is the cause of much morbidity and most of the mortality in cystic fibrosis (CF) patients.
The high prevalence of P. aeruginosa infections in CF is related to the microbe's large genome and mechanisms of adaptation to the CF lung environment, the host immune system and antibiotic resistance.
Among a wide range of P. aeruginosa metabolites involved Cited by: 1. Pseudomonas aeruginosa and the in vitro and in vivo biofilm mode of growth. Høiby N(1), Krogh Johansen H, Moser C, Song Z, In vivo properties of Pseudomonas aeruginosa book O, Kharazmi A.
Author information: (1)Department of Clinical MicrobiologyRigshospitalet and Institute of Medical Microbiology and Immunology, Juliane Maries University of Copenhagen, DK Cited by: In vivo growth of Pseudomonas. Many successful antibiotic chemotherapies target elements that alter mechanical properties of bacteria, and yet a global view of the biochemistry underlying the.
Assembling the latest research by an international group of contributors, this volume covers the epidemiology, pathogenesis, clinical features, and control measures of this elusive microorganism. It w. Morphological and tinctorial properties: Pseudomonas aeruginosa belongs to the family Pseudomonadaceae.
Gram - straight rods, arranged singly, in pairs or in short chains. Mobile. Do not form spores have drank (pili).
Under certain conditions, can produce extracellular slime capsule polysaccharide. Cultural properties: obligate aerobes that grow well on simple nutrient media. In vivo identification of sialic acid as the ocular receptor for Pseudomonas aeruginosa Article (PDF Available) in Infection and Immunity 51(2) March with 12 Reads How we measure 'reads'.
Abstract. An R factor from Pseudomonas aeruginosa, which confers resistance to penicillins, kanamycin, and tetracycline, was studied in Escherichia coli K The R factor could coexist with F-like or I-like plasmids and therefore constituted a novel compatibility group.
The R factor was transferable from E. coli to bacterial genera outside the Enterobacteriaceae (Pseudomonas and members of Cited by: Pseudomonas aeruginosa is a leading cause of nosocomial infections, and resistance to virtually all approved antibacterial agents is emerging in this pathogen.
To address the need for new agents to treat MDR P. aeruginosa, we focused on inhibiting the first committed step in the biosynthesis of lipid A, the deacetylation of uridyldiphosphoO Cited by: P.
aeruginosa is an opportunistic pathogenic bacterium responsible for both acute and chronic infections. Beyond its natural resistance to many drugs, its ability to form biofilm, a complex biological system, renders ineffective the clearance by immune defense systems and antibiotherapy.
The objective of this report is to provide an overview (i) on P. aeruginosa biofilm lifestyle cycle Cited by: Abstract. Pseudomonas aeruginosa isolates usually appear as non-mucoid colonies when cultured on agar media, but respiratory isolates from patients with cystic fibrosis (CF) characteristically produce mucoid colonies (Fig.
It is important at this point to make the distinction between the exopolysaccharide produced by mucoid P. aeruginosa and slime, which is a loosely defined material Cited by: Pseudomonas aeruginosa Introduction. Pseudomonas aeruginosa is a Gram-negative, aerobic rod bacterium of the Pseudomonadaceae family (a member of the Gammaproteobacteria).
aeruginosa contains 12 other members in its family. Similar to other members of the genus, P. aeruginosa is commonly found in soil and water as well as in plants and by: 2.
Other articles where Pseudomonas aeruginosa is discussed: ear disease: Perichondritis: due to a particular microorganism, Pseudomonas aeruginosa. There is a greenish or brownish, musty or foul-smelling discharge from the outer-ear canal, while the affected outer ear becomes tender, dusky red, and two to three times its normal thickness.
Prompt antibiotic treatment is necessary to prevent. Pseudomonas aeruginosa Used in Our Work Two cultures of Pseudomonas aeruginosa, obtained from lesions infected with this organism, have been employed for the production of the Pyol compounds in our investigation.
One of these, P-SLU, a stock culture. This chapter discusses the spectrum of infections caused by Pseudomonas aeruginosa. Hospital-acquired pneumonias, urinary tract infections, surgical-site infections, and bacteremias are among the nosocomial infections frequently caused by P.
aeruginosa. The major cause of high morbidity and mortality in cystic fibrosis (CF) is chronic respiratory infection with P.
by: The book edited by Professor P. Cornelis on molecular approaches to Pseudomonas is an excellent source of information on the biology of P.
aeruginosa PAO and P. putida KT The P. fluorescens strains have not received much attention and perhaps nobody can predict how long the eclipse will by: Introduction.
Pseudomonas aeruginosa is a Gram-negative, rod-shaped, asporogenous, and monoflagellated bacterium. It has a pearlescent appearance and grape-like or tortilla-like odour.
aeruginosa grows well at 25°C to 37°C, and its ability to grow at 42°C helps distinguish it from many other Pseudomonas species.P. aeruginosa is a ubiquitous microorganism which has the ability to survive. Abstract. Pseudomonas aeruginosa is an important cause of nosocomial pneumonia associated with a high morbidity and mortality rate.
This bacterium expresses a variety of factors that confer resistance to a broad array of antimicrobial agents. Empirical antibiotic therapy is often inadequate because cultures from initial specimens grow strains that are resistant to initial by: CF An engineered lysin targeting Pseudomonas aeruginosa, including extensively resistant strains ContraFect announced its next product candidate, CF, in December CF was selected for further development based on its potent in vitro bactericidal and antibiofilm activity and in vivo activity and tolerability in preclinical.This book is certainly worth a place on a pseudomonad aficionado's bookshelf.
The treatment of specialized topics, in particular lipids, provides a valuable means to cross-reference with other areas of pseudomonas research. It should also encourage a wider audience to appreciate the diverse properties of the pseudomonads and their importance in.